Leflunomide Analogues as Potential Antiinflammatory Agents.
نویسندگان
چکیده
منابع مشابه
Kavain analogues as potential analgesic agents.
BACKGROUND Kavalactones are pharmacologically active compounds present in preparations of the root trunk of Piper methysticum Forst, known as kava. This work describes the analgesic activity of some synthesized analogues of synthetic kavain, which is the main component of kava. METHODS The essays were initially performed against the writhing test in mice, and the most promising compound was a...
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A new series of tetrahydroindeno[1,2-b]pyrrole-3-carboxylate derivatives(4) were synthesized by reaction of 5-amino-2-mercapto benzimidazole with 1,3-dicarbonyls and activated carbonyl compounds using ceric ammonium nitrate catalyst by a three component one-pot reaction. Structures of these compounds were established on the basis of infrared spectroscopy, proton nuclear magnetic resonance, carb...
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The glycosylation of 1,3,4-oxadiazole-2-thiones has been performed with peracetylated β-pyranosyl bromide in the presence of potassium carbonate. Deprotection of acetylated thioglycosides was necessary for increasing their antibacterial effects. The structure of nucleosides were confirmed by 1H NMR, 13C NMR and HRMS. The anomeric protons of nucleosides c1–4 were assigned to the doublet, confirm...
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متن کاملDesign and Synthesis of 4-flurophthalimides as potential anticonvulsant agents
Objective(s): Anticonvulsant activity of phthalimide was discovered in 2000 by molecular hybridization of thalidomide and ameltolide. In our previous research we have reported some new 4-substituted derivatives of phthalimide with good activity against the tonic and clonic seizures Material and Methods: A series of novel 4-flurophthalimides that designed using bioisosteric replacement were synt...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 2003
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.51.313